| Summary: | 博士 === 中國醫藥大學 === 藥物化學研究所博士班 === 102 === Propofol is extensively used in the intensive care setting as a
sedative. As a common and safe anesthetic agent, propofol provides fast
onset, deep sedation, rapid cognition and functional recovery. Because of
propofol ''s lipid solubility, the formulation design mainly for oil-in-water
injectable lipid emulsions. Injectable emulsion common contains the
active ingredient, soybean oil, glycerol and lecithin. The general
compositions of emulsion have three components consisting of water, oil
and surfactant. This drug delivery approach finds its roots in the now
well-established parenteral nutrition formulations. Medium chain
triglyceride/long chain triglyceride (MCT/LCT) was developed to address
the problems associated with the LCT. Recent interest in utilizing lipid
emulsions for delivering lipid soluble therapeutic agents, intravenously,
has been continuously growing due to the biocompatible nature of the
lipid-based delivery systems. Because propofol is lipophilic drug, we
intend to experimental design establish an emulsifying technology
platform to develop a new generation of general anesthetic propofol
MCT/LCT injectable emulsion and long-term and accelerated stability
study. In clinical practice, it is also critical to have well-documented
information about the drug stability and the stability of an opened drug
formulation after dilution in various vehicle. Currently, there are many
manufacturers can produce large volume parenteral solutions, while the
pharmaceutical infusion containers used in different materials. In this
study, we mimicked the clinical environment to investigate the
physicochemical stability of propofol MCT/LCT emulsions and the
compatibility of propofol MCT/LCT in differ material containers. This
comprehensive information of propofol MCT/LCT provided hospital
medication before using propofol and to improve drug quality and protect
the safety of person medication.
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