Psychological analysis of hepatitis C drug abuser and discuss the effect of MMT on fatty acid metabolism in drug abuser

• Main Authors: Chiao-Yu Tsai, 蔡蕎羽
• Other Authors: 楊惠婷
• Format: Others
• Language: zh-TW
• Published: 2014
• Online Access: http://ndltd.ncl.edu.tw/handle/82958757908006917591

碩士 === 中國醫藥大學 === 營養學系碩士班 === 102 === In this study, we recruited 89 heroin users from methadone clinics, prisons or drug abuser treatment center. People who were had medical problems, neurological diseases, HIV, mental handicap, and other barriers were excluded from the study. The purpose of this study was the effect of methadone maintenance treatment (MMT) for drug abusers also suffering hepatitis C on fatty acid metabolism, the degree of depression and gene polymorphism. The 89 drug abusers were divided into two groups, drug abusers with or without hepatitis C. The patient characteristics, biochemical values (SGOT, SGPT, r-GT), types of drug abuse, prevalence of blood-borne diseases, and scales were analyzed. We analyzed the erythrocyte membrane phospholipid of before and after methadone maintenance treatment. Furthermore, we investigated polymorphisms in genes of fatty acid metabolism in heroin users. The results showed that before MMT, drug abusers also suffering hepatitis C had sleep disturbances and lower quality of life scores than after. The difference of erythrocyte membrane phospholipid between MMT before and after, no matter drug abusers also suffering hepatitis C or not, the SFA was significantly increased, PUFA and AA/EPA ratio were decreased significantly. Further, after MMT, AA/EPA ratio of drug abusers also suffering hepatitis C was higher than drug abusers without hepatitis C significantly. It might result in drug abusers also suffering hepatitis C had high prevalence of psychiatric disorders. On the other hand, there is no difference in the allele frequencies of PLA2 and PPAR gamma polymorphisms. There is difference in the allele frequencies of FADS1, FADS2 and FADS3 polymorphisms, but there is no significant difference with n6/n3 PUFAs.