Study on Corrosion Resistance and Biological Responses of Zr62.5Cu22.5Fe5Al10 Bulk Metallic Glass Treated by Nitrogen Plasma Immersion Ion Implantation

• Main Authors: Hsun-Miao Huang, 黃焄妙
• Other Authors: Her-Hsiung Huang
• Format: Others
• Language: zh-TW
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/56021841059803739364

碩士 === 國立陽明大學 === 口腔生物研究所 === 101 === Zirconium (Zr)-based bulk metallic glass (BMG) has been considered to be potential biomaterial in recent years because of its better corrosion resistance, higher yield strength and relatively lower elastic modulus comparing to current biomedical alloys. However, BMG is prone to pitting corrosion while it contacts with simulated physiological solution. This leads to the release of metallic ions from BMG, which may cause biological side effects. In this study, in order to increase the corrosion resistance, especially pitting corrosion resistance, of BMG without changing its bulk crystalline, nitrogen plasma immersion ion implantation (N-PIII) was used to form a protective nitride film with nanoscale thickness on the nickel-free Zr62.5Cu22.5Fe5Al10 BMG. The surface properties, corrosion resistance and biological responses of the Ni-free Zr62.5Cu22.5Fe5Al10 BMG treated with N-PIII were investigated. Results showed that the surface of BMG after N-PIII treatment (N-BMG) mainly contained ZrO2 and ZrN; the N atoms mainly concentrated under a depth of approximately 10 nm. There was no significant difference in crystal structure, surface topography, surface wettability and surface roughness between BMG and N-BMG. As for the corrosion resistance, the presence of a protective nitride-oxide film on BMG surface led to higher pitting potential and corrosion potential and lower corrosion rate. As for the blood responses, N-BMG showed higher platelet adhesion number and better platelet activation than BMG. As for the cell responses, BMG and N-BMG were non-cytotoxic and had no difference in adhesion and differentiation of human bone marrow mesenchymal stem cells; however, N-BMG showed higher cell proliferation. According to the abovementioned results, we would conclude that N-PIII treatment enhances the corrosion resistance, blood responses and cell responses of Ni-free Zr62.5Cu22.5Fe5Al10 BMG. This fact favors the potential applications of N-BMG as biomedical implants.