| Summary: | 碩士 === 國立陽明大學 === 醫學工程研究所 === 101 === Silica demonstrated several characteristics which are advantageous to be a carrier material for PSs. First, it is relative transparent, thus light can penetrate and activate the PSs loaded in the shell or inside the carrier. Second, it’s rid and non-degradable, so the PpIX loaded in silica would not be released into the surrounding environment and cause dark cytotoxicity. Third, the biocompatibility of silica was good, and it would not have harmful effects to normal tissues.
In this study, Protoporphyrin IX (PpIX, a photosensitizer) was loaded in the shell of silica hollow spheres with the expectation that PpIX-loaded silica hollow spheres (PpIX-SHS) might be employed as a PDT agent with ultrasound image contrast. The PpIX-loaded silica hollow spheres were fabricated using DMDES (dimethyldiethoxysilane) which could be transformed into PDMS (polydimethylsiloxane) templates. The PDMS templates were crosslinked via TEOS (tetraethoxysilane), followed by the addition of PpIX and APTES (3-aminopropyl triethoxysilane) to obtain biocompatible silica hollow spheres with the PpIX-containing shell.
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