| Summary: | 碩士 === 國立陽明大學 === 醫務管理研究所 === 101 === Background:
Colorectal cancer tops all cancers in its incidence rate of in Taiwan. Standardized mortality ratio of colorectal cancer in Taiwan is 1.4 times as high as is found in the U.S.A. It is therefore vital that much has to be done about prevention and research in the fight against this disease. Based on the previous studies, regular use of aspirin and other non-steroidal anti-inflammatory drugs, NSAIDs for short, have proved to be effective in lowering the incidence of colorectal cancer. This research is conducted on the basis of samples coming from database provided by NHI, in the hope of confirming the preventive potency of these drugs.
Object:
Explore the general population long-term regular user of Non-Steroidal Anti-inflammatory Drugs reduce the risk of colorectal cancer.
Method:
The method of retrospective cohort study is applied, using longitudinal health insurance database as its source of data. Claims data from 2000 to 2009 involving patient’s with or without colorectal cancer aged over forty are obtained. Details of each patient’s NSAID prescription are analyzed and consecutive users of the NSAIDs are labeled as regular users. According to drugs taken, the regular NSAIDs users are further categorized into (1) regular aspirin users, (2) regular non-aspirin of NSAIDs users, and (3) regular mixed NSAIDs users. By applying different methods including multiple adjustments for age, gender, and comorbidity, age and gender matching, or propensity score matching, risks to colorectal cancer in various models are estimated and used to examine the associations between regular use of NSAIDs and colorectal cancer.
Result:
In all, 334, 420 patients are included in the statistical analysis. As to the relationship between non-steroidal anti-inflammatory drug use and incidence of colorectal cancer, it is found that regular users of non-steroidal anti-inflammatory drugs have a 0.78-0.88 risk ratio as compared with non-regular users. It is also found that regular users of aspirin have a risk ratio of 0.74-0.83 in comparison with non-regular users. Both findings are statistically significant.
Conclusion:
It is revealed that incidence of colorectal cancer is enormously lowered among regular users of aspirin and non-steroidal anti-inflammatory drugs. In contrast, regular use of non-aspirin which is non-steroidal anti-inflammatory drug or mixed use does not show preventive effect.
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