| Summary: | 碩士 === 國立陽明大學 === 生物醫學資訊研究所 === 101 === There have been numerous reports on the role of human papillomavirus (HPV) on the etiology of breast cancer. However, there are very few studies comparing these two diseases holistically in order to develop a model to predict and possibly prevent diseases. To our knowledge, this study using disease-disease association data-mining to analyze viral warts and breast cancer is the first study to be conducted in Taiwan.
Backgrounds:
The role of viruses in the etiology of breast cancer has been acknowledged for over 100 years. It is estimated that viruses may be the cause of approximately 15% of all human cancers. In females, close to 20% of all cancers may be linked to viral infections, with cervical cancer being the most notable example. These percentages represent a significant portion of cancer instances that are attributed to viruses. Virus infections may initiate cancer pathways due to errors in the cellular repair system, but additional risk factors such as the environment, behavior, or genetics are needed to perpetuate this process.
Materials and Methods:
An initial screening process to determine the basic level of association between viral warts and female breast carcinoma was conducted using Taipei Medical University’s Medical End-User Computing (MEUC) system in which the International Classification of Diseases (ICD-9) codes were used. A Q-value that represented the association factor between these two diseases was calculated through this system.
Following the initial screening, cohort data comprising of one million patient data from 2000-2008 and then 23 million population data from 1999-2008 from Taiwan’s National Health Insurance (NHI) database was used to further examine the association between viral warts and female breast carcinoma. The patients were categorized into three groups: breast cancer only, viral warts only, and breast cancer and viral warts. The odds ratio for each age group was calculated through SPSS as well as the associated p-values.
Conclusion:
Our studies indicate that women who develop viral warts are at a slightly higher risk of developing breast cancer than women who develop breast cancer first. This value could indicate that women within this age group are at a higher risk for developing breast cancer than other women in any other age group. HPV might play less important role in mature breast cancer than in the early stage of breast cancer.
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