Biocompatibility and locomotion analysis of zebrafish(Danio rerio) with magnetic nanoparticles effect

• Main Authors: Jing-Jie Shen, 沈靖傑
• Other Authors: Ping-Hung Yeh
• Format: Others
• Language: zh-TW
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/63974375316034412741

碩士 === 淡江大學 === 物理學系碩士班 === 101 === Magnetic nanomaterial has extensive potential for many applications, such as magnetic recording media, localize heating treatment, and drug delivery systems for pharmaceutical cure in vivo. However, the toxicology and biocompatibility of magnetic nanoparticles(NPs) should be studied. In this work, the security and impact of magnetic NPs, iron oxide, were investigated by injecting and feeding iron oxide NPs into zebrafish embryos and adult zebrafish to check the ethology, respectively. From death, mortality, hatching, deformity rate and morphology during embyro-larval stages, and ethology analysis for adult zebrafish, we infer that the toxicity of iron oxide nanoparticles is a dose-dependent tendency in zebrafish. When the feeding magnetic NPs concentration was increasing, the magnetic field will strong affect the moving trace of the zebrafish, like an invisiable wall to limit the movement.