Copper-catalyzed domino reaction to synthesize phenanthridinone scaffold

• Main Authors: Yi-Sheng Wu, 吳宜聲
• Other Authors: Jen-Chieh Hsieh
• Format: Others
• Language: zh-TW
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/88907423615915999258

碩士 === 淡江大學 === 化學學系碩士班 === 101 === The 1st Part: An efficient Cu-catalyzed O-arylation was carried out by involving phenols with iodoarenes to afford various substituted diarylether derivatives with a small amount of Cu2O and 1H-imidazole-4-carboxylic acid as catalytic system under mild conditions, which provided good to excellent yields with good tolerance of functional groups. The 2st Part: Copper-catalyzed domino reaction of 2''-bromo-2-cyanobiphenyl through C-N bond formation under ligand-free and milder conditions to synthsize phenanthridinone scaffold. The reaction tolerates a variety of substrates and provides biologically important phenanthridinone derivatives.