| Summary: | 碩士 === 淡江大學 === 化學學系碩士班 === 101 === The 1st Part:
Variously synthetic methods of 3,3 spiro-oxindole derivatives were carried out and comparison of the mechanisms for different pathway was discussed.
The 2st Part:
An efficient copper-catalyzed intramolecular N-arylation was carried out by involving 2,2-substituted 2-(2-bromoaryl)acetamide to afford various substituted oxindoles with a small amount of Cu2O and benzene-1,2-diamine as catalytic system under aerobic conditions, which provided good to excellent yields with tolerance of wide variety of substrates.
The 3st Part:
An efficient copper-catalyzed intramolecular N-arylation was carried out by involving 2’-bromo-2-cyanodipheny to afford variously substituted phenanthridinones with a small amount of CuI and Sodium hydroxide at 100 oC, which provided good to excellent yields with tolerance of wide variety of substrates.
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