Cooper-Catalyzed C-N cross-coupling reaction: the application for the synthesis of oxindoles
碩士 === 淡江大學 === 化學學系碩士班 === 101 === The 1st Part: An efficient and novel procedure for the copper catalyzed domino coupling reaction has been developed, which afforded various oxindoles in good to excellent yields with tolerance of various substituents. In addition, this method could be applie...
| Main Authors: | , |
|---|---|
| Other Authors: | |
| Format: | Others |
| Language: | zh-TW |
| Published: |
2013
|
| Online Access: | http://ndltd.ncl.edu.tw/handle/3ecn9g |
| Summary: | 碩士 === 淡江大學 === 化學學系碩士班 === 101 === The 1st Part:
An efficient and novel procedure for the copper catalyzed domino coupling reaction has been developed, which afforded various oxindoles in good to excellent yields with tolerance of various substituents. In addition, this method could be applied to synthesize coerulescine in short steps with high total yields.
The 2st Part:
An efficient copper-catalyzed intramolecular N-arylation was carried out by involving 2,2-substituted 2-(2-bromoaryl)acetamide to afford various substituted oxindoles with tiny loadings of Cu2O and benzene-1,2-diamine as catalytic system under aerobic conditions, which provided good to excellent yields with tolerance of wide variety of substrates.
|
|---|