Hydrogenated and Titanium-doped Diamond-like Carbon Thin Films for Biocompatibility and Antibacterial Applications

• Main Authors: Rong-Teng Sie, 謝榮騰
• Other Authors: 林啟瑞
• Format: Others
• Language: zh-TW
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/n87snn

碩士 === 國立臺北科技大學 === 機電整合研究所 === 101 === Diamond-like carbon (DLC) films are the best materials for many applications due to their high hardness, optical transparency, electrical resistance, chemical inertness, and low coefficient of friction. Also, it is well known that modified DLC films with doped elements would enhance those characteristics mentioned above, especially ensure high bio/haemo-compatiblility. In this study, H-free, hydrogenated and titanium-doped DLC thin films were deposited onto silicon, Polyethylene terephthalate (PET) and Ti6Al4V substrate by R.F. unbalance magnetron sputtering technique. It is shown that the experiment parameters had significant effects on surface microstructure, roughness, wettability, optical transparency, chemical inertness, biocompatibility and haemocompatiblility. In bio-tests, MG63 cell, PC12 cell and Hela cell were cultured on substrates of Si、Ti6Al4V、PET and DLC thin films. The vitro tests revealed that MG63 and Hela cell had a higher number of cells grown on the DLC thin films, and PC12 cell just grown on hydrogenated DLC thin film. The haemo tests showed that DLC thin films had no cytotoxicity, and they both had excellent anticoagulatory effect. In antibacterial test, H-free and titanium-doped DLC thin film had a fewer amount of colon bacillus attached than other materials.