| Summary: | 碩士 === 國立臺灣科技大學 === 機械工程系 === 101 === The general treatments of androgenetic alopecia include finasteride, minoxidil, and hair transplantation. But the effects are still patient-dependent. In recent years, scholars have found that implanting mixtures of dermal papilla cells and epidermal cells into bald areas could promote hair follicle regeneration. However, most cell implantations nowadays use surgeries or manual syringe-ejection, which are time-consuming in preparations and cells filling. To shorten the lead time, to accelerate the implantation speed, and to control the implantation depths, this study planned to develop a continuous double-syringe cell implanter that can store and implant two kinds of cells.
The design concepts of this cell implanter utilize syringes as containers for cells storage, and the implanter can implant cells in the expected orders. In particular, two kinds of cells were filled in the syringes separately and loaded in the implanter. Through the linear actuators and corresponding mechanisms, the syringe was engaged to the needles and ejected the cells. The slider-crank mechanism and the motor were adopted to alternate the two syringes. The components of the implanter was designed in the 3D CAD software and fabricated by SDM (Shape Deposition Manufacturing) process or PolyJet™ technology, ones of the Additive Manufacturing techniques. The assembled prototype was used to perform simulated implantation tests on nude mice. Red and blue gels, imitating two kinds of cells, were implanted into mice’s back. Observations were conducted on the back’s surfaces and also from the inside surface after cutting off the skin. The results showed that the continuous double-syringe cell implanter can successfully implant two kinds of cells into the same areas. The implantation orders and quantities are controllable. Moreover, the steps of exchanging needles and syringes are easy and fast, and the implantation effects and successful rates are satisfying.
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