| Summary: | 碩士 === 國立臺灣科技大學 === 電子工程系 === 101 === Resting state networks which relate to the alterations of coherent intrinsic neuronal activity based on blood oxygen level-dependent (BOLD) fluctuations can be observed in the resting state functional magnetic resonance imaging (rsfMRI). Among all resting state networks, default mode network (DMN) has been shown to exhibit reduced activation in the presence of high cognitive demand and has been used to investigate the neuronal dysfunctions. Recently, there are several studies showing that functional activity can be related to the baseline metabolic levels, such as glutamate, glutamine and GABA. Based on our previous results, proton echo planar spectroscopy imaging (PEPSI), as a fast magnetic resonance spectroscopic imaging (MRSI) method, is able to acquire the distribution of brain metabolites with acceptable reproducibility in the medial wall. As brain regions in DMN can be covered mostly by a sagittal plane near the medial wall. In this study, we try to combine rsfMRI and MRSI and use PEPSI to investigate the baseline level of 5 kinds of neurochemical metabolites (NAA Cre Cho mI Glx) in DMN regions and non DMN regions in normal subjects. The results successfully combine rsfMRI and MRSI, showed that there are significant differences metabolites in NAA, Cre and Glx in DMN region and non-DMN region.
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