| Summary: | 碩士 === 國立臺灣科技大學 === 醫學工程研究所 === 101 === The pulmonary drug delivery system becomes an attractive strategy for the delivery of anti-inflammatory drugs for treating both systemic and local diseases, due to its less invasive property and lower first pass effect. Magnolol was found to have anti-inflammatory and anti-oxidative abilities in the preclinical experiments. However, the poor solubility and the poor suspension property of magnolol have hindered its success. In this study, the spray - dried microparticles containing biodegradable nanoaprticles were developed for improving the pulmonary delivery efficiency of magnolol.
The results showed that the particle size of microparticles containing nanoaprticles is 3. 45 ± 0.83μm, which is suitable for pulmonary delivery. The encapsulation efficiency of microparticles containing magnolol loaded biodegradable nanoaprticles is about 10.93 -20.42 %. In vitro release results indicate that the magnolol loaded nanoaprticles can continuously release magnolol within 48 hours. Microparticles containing magnolol loaded biodegradable exhibited a great aqueous dispensability and low cytotoxicity. It also showed better inhibitory effects on NO and TNF-α production from LPS -activated RAW 264.7 cells when compared to other vehicles at the same condition. Also, microparticles containing magnolol loaded biodegradable nanoparticles showed better inhibitory effects on superoxide production from LPS -activated RAW 264.7 cells.
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