Computerized Detection and Delineation of Calcified Vessels in Digital Mammography

• Main Authors: Jie-Zhi Cheng, 鄭介誌
• Other Authors: Chung-Ming Chen
• Format: Others
• Language: en_US
• Published: 2012
• Online Access: http://ndltd.ncl.edu.tw/handle/46190175822037131812

博士 === 國立臺灣大學 === 醫學工程學研究所 === 101 === As a potential biomarker for women''s cardiovascular and chronic kidney diseases, breast arterial calcification (BAC) in mammography has become an emerging research topic in recent years. To provide more objective measurement for vascular structures with calcium depositions in mammography, a new computerized method is introduced in this paper to delineate the calcified vessels. Specifically, we leverage two underlying cues, namely calcification and vesselness, into a multiple seeded tracking with uncertainty scheme. This new vessel-tracking scheme generates plenty of sampling paths to describe the complicated topology of the vascular structures with calcium depositions. A compiling and linking process is further carried out to organize the sampling paths together to be the vessel segments that likely belong to the same vessel tract. The proposed method has been tested on 63 mammograms. For performance evaluation, four sets of our computer-estimated results are evaluated by the two sets of manual delineation results from two experts, by using three assessment metrics and two clinical metrics. The experiment results confirm the efficacy and stability of the proposed method, and also indicate that the proposed method can be potentially used as a convenient BAC measurement tool to replace the trivial and tedious manual delineation tasks.