Anthracenedione-methionine conjugates as a novel class of topoisomerase II-targeting anticancer drugs with favorable clinical profiles
博士 === 國立臺灣大學 === 微生物學研究所 === 101 === Antitumor anthracenediones, including mitoxantrone (MX) and ametantrone (AT), intercalate into DNA duplexes and induce topoisomerase II (TOP2)-mediated DNA break via a proposed “misalignment” mechanism. However, structure-associated multi-drug resistance and DNA...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Others |
| Language: | en_US |
| Published: |
2013
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| Online Access: | http://ndltd.ncl.edu.tw/handle/54888596998183282390 |