Sintering and biodegradation behavior of calcium sulfate with a small amount of sintering additives

• Main Authors: Yi-Chun Tsung, 宗怡君
• Other Authors: Wei-Hsing Tuan
• Format: Others
• Language: zh-TW
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/52592700428083137714

碩士 === 國立臺灣大學 === 材料科學與工程學研究所 === 101 === Calcium sulfate (CS) has been used as a bone graft substitute for more than 100 years. It exhibits many desired properties as a bone substitute. These properties include biocompatible and biodegradable. The aim of the present study is to investigate the sintering and biodegradation behavior of the calcium sulfate. A small amount of sintering additives was used to improve the sinterability of CS. These additives are SiO2, P2O5, CaO, NaHCO3 and Ag. The additives are added into CS and then sintered at 1100°C. Several SiO2–CaO–P2O5–Na2O bioactive glasses exhibit excellent proliferation and differentiation for osteoblasts. They are also potential substitutes to form new bone. The glass powders were also added into CS to modify its properties. The results demonstrate that a small amount of additives or glass affects little on the density. A reaction phase is formed; it inhibits the growth of CS grains during the sintering. The compressive strength of the specimens is increased after adding the additives. The degradation rate is slower than that of the pure CS specimens. All these results suggest that by adding a small amount of additives can improve the properties of CS. The composites investigated in the present study could be used for further application as a bone substitute.