Applicability and limitations of MR tracking and Perfusion change after intracerebral stem cell Implantation in chronic stroke patients

• Main Authors: Chao-Chun Lin, 林昭君
• Other Authors: 鍾孝文
• Format: Others
• Language: en_US
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/29515686907988165416

博士 === 國立臺灣大學 === 生醫電子與資訊學研究所 === 101 === Stroke is the 3rd leading cause of death in Taiwan on 2010. In the chronic stage, no treatment currently exists to restore lost neurological function after stroke. A growing number of studies highlight the potential of stem cell transplantation in animal model as a novel therapeutic approach for stroke. One phase II clinical trial in our institution studied the therapeutic effects with intracerebral peripheral blood hematopoietic stem cell (CD34+) implantation for chronic stroke patients. This regular MRI follow-ups are aimed to noninvasively monitor the fate, behavior of the implanted stem cells labeled with superparamganetic iron oxide by R2* relaxivity. Besides, since animal studies hypothesize that CD34+ cells may play a positive role in neuroregeneration by inducing neovascularization in the ischemic zone, we want to test the hypothesis of increased cerebral blood flow and volume associated with stem cell implantation, also by MR T2* perfusion sequence.