| Summary: | 博士 === 國立臺灣大學 === 生醫電子與資訊學研究所 === 101 === As balanced steady-state sequence becomes a popular MR imaging modality for its terrific efficiency in terms of SNR per TR, unbalanced steady-state sequences draw more and more attention for their clinical applicability. In particular, dual-echo in the steady-state (DESS) sequence acquires diverse signals of two different signal pathways, so that tissue properties may be revealed.
In this thesis, we aim to exploit the sampling ability of unbalanced steady-state sequence to investigate signal evolutions of different pathways. A variant of DESS sequence is designed and applied to brain imaging. To be specific, transverse relaxation rates and the internal field perturbation are simultaneously extracted from signals acquired by our proposed compact method, and the extracted information could be valuable in estimating brain iron concentration.
To obtain a proper set of scanning parameters, numerical simulations are employed to evaluate sequence performance. In addition, potential image artifacts are discussed, and two possible applications are proposed in a later chapter in this thesis. We expect this work may advance the current development of unbalanced steady-state sequences, and the proposed sequence would be a handy imaging sequence for other applications as well.
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