Study on surface modification of Ti alloy by micro-powder technology and its application on biocompatibility

• Main Author: 范揚明
• Other Authors: Chih-Wei Wu
• Format: Others
• Language: zh-TW
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/89564974374349308982

碩士 === 國立臺灣海洋大學 === 機械與機電工程學系 === 101 === This thesis was prepared with different impact particles (Al2O3 (MS 245A, MS 300A, MS 550A) and SiC) to sandblast on TiAl6V4 substrate and with different impact particles and hydroxyapatite (HA) to co-blast on TiAl6V4 substrate. Finally, this thesis uses the previous substrates to do cell culture (osteoblast-like cell, MG 63) for biocompatibility studies. The impact experiments using four particles, namely MS245A (Al2O3, Φ = 50 ~ 250μm), MS300A (Al2O3, Φ = 30 ~ 70μm), MS550A (Al2O3, Φ = 10 ~ 20μm), SiC (Φ = 50 ~ 250μm). This thesis uses the dental sandblasting machine for using 6 bar air pressure to sandblast on substrste surface. In order to increase the surface roughness and micron recess structure, this thesis uses the Al2O3 and SiC particles. Later, the HA powder is placed on sandblasting chamber of dental machine and uses 6 bar air pressure through the nozzle for the co-blasting process to impact on TiAl6V4 sandblasted substrate, and to explore its surface roughness and hydrophobicity on each case. When the processing of substrate surface is completed, the osteoblast explants overlying TiAl6V4 substrate of sandblasting with different particles blasted with a double HA powder co-blasting processing. Respectively, one day, four days and seven days do MTT assay, as cell activity indicators (qualitative); simultaneously ALP assay quantitatively.