| Summary: | 碩士 === 國立中山大學 === 海洋生物科技暨資源學系研究所 === 101 === Most Asians consider fair skin to be a key element of beauty. According to market statistics (source: Euromonitor International), in 2012, cosmetics accounted for a revenue of more than $430 billion in global markets. Some of these cosmetics are used for purposes other than beauty; ‘cosmeceutical’ applications can be utilized for functions or mechanisms to soothe skin conditions. For example: postinflammatory hyperpigmentation, which usually accompanies disorders associated with melanogenesis, is caused by dermatological diseases such as contact dermatitis and atopic dermatitis or by skin damage due to UV exposure. Some of the widely used skin-whitening agents in cosmetic products or for hyperpigmentation diseases, such as hydroquinone and arbutin, are toxic and, hence, have their limitations. Findings of our preliminary anti-inflammatory screening procedure showed that a marine-derived compound significantly inhibited the expression of lipopolysaccharide-induced proinflammatory protein iNOS in murine macrophage-like RAW264.7 cells. The aim of this study was to find a safer and more effective compound than those currently in use, with anti-inflammatory, anti-melanogenic or other applicable properties for future cosmeceutical or medical use. Our results indicated that the marine-derived compound could effectively inhibit pigmentation likely by the potential downregulation of tyrosinase activity; furthermore, the compound also demonstrated low cytotoxic effect dose on B16-F10 murine melanoma cells. We also found that the marine-derived compound could suppress melanin formation while sustaining delivery treatment in the zebrafish model, without having any toxic effects. Results of our in vitro and in vivo biological assays showed that the synthetic marine-derived compound possesses anti-inflammatory, anti-melanogenic and anti-oxidative properties, with potential application in medical cosmetology.
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