The role of miRNA in regulation and their therapeutic potential in breast cancer

• Main Authors: Hsieh-chun Lee, 李協駿
• Other Authors: Hurng-Wern Huang
• Format: Others
• Language: zh-TW
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/997ysg

碩士 === 國立中山大學 === 生物醫學研究所 === 101 === Breast cancer is one of the most leading carcinomas in women (23% in woman cancer). The 5 year survival rate in the early stage of breast cancer is high, however, the survival rate decrease rapidly in late stages. In the scope of new therapeutics of breast cancer, MicroRNAs (miRNAs) plays roles in many aspects. MiRNAs are small, non-coding single-stranded RNA molecules (18-30 nt) that regulate target gene expression in post-transcriptional and mRNA degrading process. This document discuss about the requirement of miRNAs which not only functioning in normal mammary gland development but also play roles of oncogenic or tumor suppressor pathways, and miRNAs also has been established on breast cancer progression, prognosis and therapeutic efficiency. We also summarize parts of well-known miRNAs which play the key roles during mammary gland development, in normal breast stem cell and breast cancer stem cell maintenance, and oncogenic and tumor suppressor miRNAs regulate their target genes which involved in cell proliferation, migration, metastasis and prognosis of breast cancer. At last, we will discuss the progress of miRNAs application in breast cancer therapy.