Relation between Oxidative Damage and Biomarkers of Antioxidants Capacity among Engineered Nanoparticles Manufacturing Workers

• Main Authors: Hsu, Yuan-Ting, 許媛婷
• Other Authors: Lai, Ching-Huang
• Format: Others
• Language: zh-TW
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/47584223752920651757

碩士 === 國防醫學院 === 公共衛生學研究所 === 101 === To date, artificial nanomaterials have been widely used in our daily life. The engineered nanoparticles manufacturing workers were susceptible to nanoparticle exposure. Because of the related small particle size, nanoparticles penetrate easily into human cells, produce reactive oxygen species (ROS), deplete endogenous antioxidants, lead to antioxidant imbalance, and cause oxidative DNA damages. The aim of this study was to evaluate the relationships between different antioxidants and oxidative stress caused by nanoparticles to manufacturing workers. We conducted a longitudinal study between 2009 to 2012, 61 nanoparticles manufacturing workers were recruited. We used urinary and plasma 8-hydroxy-2, deoxyguanosine (8-OHdG), 8-iso-prostaglandin F2α (8-iso-PGF2α), superoxidase dismutase (SOD), glutathione peroxidase (GPx), and oxygen radical absorbance capacity (ORAC) as oxidative DNA damage, lipid peroxidation marker, and antioxidative capacity, respectively. In the present study, we have found an increased trend between nanoparticles exposure and biomarkers that reflect 4-year trend oxidative damage. From Random effect linear mixed model adjusted for confounders, there was a negative association between urinary 8-OHdG and antioxidant (regression coefficient (β), βSOD=-0.04, 95%C.I.=-0.08, -0.004, βGPx=-0.02, 95%C.I.=-0.03, -0.01). Otherwise, a positive association between 8-iso-PGF2α and antioxidant SOD, GPx (βSOD=0.54, 95%C.I.=0.44, 0.64, βGPx=0.12, 95%C.I.=0.10, 0.14).