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• Main Authors: Pei-jie Sie, 謝佩倢
• Other Authors: Yuh-ing Chen
• Format: Others
• Language: zh-TW
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/22826531349345797637

博士 === 國立中央大學 === 統計研究所 === 101 === The article considers the bioequivalence test between the test drug and patent drug under a 2×2 crossover design. If there have been some generic drugs under study, then prior information about the bioavailability of the test drugs would be available. Therefore, this article considers a Bayesian test for the bioequivalence of the two drugs based on a robust random effects model for the estimated bioavailability parameters. A real data is illustrated based on the proposed Bayesian bioequivalent test. Finally, a simulation study is implemented to investigate the performance of the proposed test.