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博士 === 國立中央大學 === 統計研究所 === 101 === The article considers the bioequivalence test between the test drug and patent drug under a 2×2 crossover design. If there have been some generic drugs under study, then prior information about the bioavailability of the test drugs would be available. Therefore,...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Others |
| Language: | zh-TW |
| Published: |
2013
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| Online Access: | http://ndltd.ncl.edu.tw/handle/22826531349345797637 |
| Summary: | 博士 === 國立中央大學 === 統計研究所 === 101 === The article considers the bioequivalence test between the test drug and patent drug under a 2×2 crossover design. If there have been some generic drugs under study, then prior information about the bioavailability of the test drugs
would be available. Therefore, this article considers a Bayesian test for the bioequivalence of the two drugs based on a robust random effects model for the estimated bioavailability parameters. A real data is illustrated based on the proposed Bayesian bioequivalent test. Finally, a simulation study is implemented to investigate the performance of the proposed test.
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