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• Main Authors: Wei-Lin Su, 蘇瑋琳
• Other Authors: Tsung-Shan Tsou
• Format: Others
• Language: zh-TW
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/10552387577769229278

碩士 === 國立中央大學 === 統計研究所 === 101 === In the fields of biotechnology and genetic engineering, continuous-time Markov chains are commonly used to describe probabilities of mutational events. The nucleotide sites in the DNA are usually assumed to be evolving independently of each other. We investigate the impacts on inference of correlation between bases at different positions in the DNA sequence. We also recommend using the robust likelihood methodology proposed by Royall and Tsou (2003) to convert the multinomial model to become robust against the misspecification of correlation. The adjusted robust multinomial likelihood could automatically incorporate the correlation structure and deliver legitimate inference.