| Summary: | 碩士 === 國立中央大學 === 化學工程與材料工程學系 === 101 === The aim of this thesis is to prepare and characterization solid dispersion based deltamethrin/syndiotactic polypropylene(sPP) filaments by the solvent method. We use the imitative wet spinning (needle injection) method to prepare deltamethrin/sPP filaments. Initial solvent screening was used to establish the form space of deltamethrin. There were 21 good solvents and two bad solvents for deltamethrin. From the form space of deltamethrin, we chose the suitable solvent which could be used to imitative wet spinning process. The melting points and glass transition temperatures of solid dispersions samples could be determined by LTDSC. FT-IR was used to observe the polymorphic form of sPP and interaction between deltamethrin and sPP. XRD was used to determine the crystallite sizes of deltamethrin in deltamethrin/sPP filaments. HSPOM was used to observe the melting and crystallization behaviors of samples. The dissolution tests were used to compare the dissolution rates in different ratios of deltamethrin/sPP filaments. Deltamethrin and sPP were immiscible in all the ratios of solid dispersions samples. The FTIR spectra did not show any peak shift which indicated that was no interaction between deltamethrin and sPP. The deltamethrin/sPP filaments with weight ratios of 10/90, 20/80, 30/70, and 100/0 gave the deltamethrin crystallite sizes of 6.9, 13.4, 18.9 and 47.1 nm, respectively. The dissolution rates of deltamethrin/sPP filaments were arranged in the descending order according to the weight ratios of 10/90 > 20/80 > 30/70 > 100/0. The Korsemeyer-Peppas model was used to fit the dissolution profiles. All n values were < 0.5 which meant that the drug was released from a porous system. From XRD patterns and dissolution profiles, we believed that the nanosized deltamethrin crystallites within the solid dispersion based filaments increased the surface area of deltamethrin which could increase the mortality of anopheles by increasing the contact area between anopheles and the insecticide.
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