Sample Size Determination for Tolerance Interval – With Application to Pharmaceutical Testing

• Main Authors: Kao, Song-Chu, 高松楚
• Other Authors: Wang, Hsiu-ying
• Format: Others
• Language: en_US
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/9ys575

碩士 === 國立交通大學 === 統計學研究所 === 101 === Tolerance is a widely used statistical tools, and has been a useful tool for pharmaceutical testing. The determination of sample size of a pharmaceutical testing has been one of important issues for pharmaceutical companies, because it does not only represent cost considerations, but also is a quality assurance.Therefore, in this study, we develop an algorithm for determining the sample size of a tolerance interval based on historical data under some criteria provided in literatures focusing on the study of determination of sample size for tolerance interval. The required sample sizes for different cases are provided in this study. A simulation study is conducted to verify the result derived from the algorithm. The method proposed in this study can help pharmaceutical companies in choosing the sample size for drugs testing.