| Summary: | 碩士 === 國立交通大學 === 生物科技系所 === 101 === In the past ten years, lots of research indicated that it has high relativity between peroxynitrite and the diseases like septic shock, cancer, neurodegenerative disease, and inflammation, etc. It’s become a trend to discover the disease earlier before it gets too late. We have developed a new contrast agent [Gd(DO3A-CF3)] that can detect peroxynitrite by 19F MRI.
In this article, we will discuss two synthetic routes about the 19F MRI contrast agent: [Gd(DO3A-CF3)]. We even try to detect peroxynitrite by 4-(4-(3-bromopropoxy)phenyl)-1,1,1-trifluorobutan-2-one(4), and with this successful result, we still keep on trying to synthesize [Gd(DO3A-CF3)].
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