Study of Chemically Modified Fiber Membrane in Rapid Test Strip

• Main Authors: Hsin-ZhanYeh, 葉欣展
• Other Authors: Yu-Cheng Lin
• Format: Others
• Language: zh-TW
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/spxxdr

碩士 === 國立成功大學 === 工程科學系碩博士班 === 101 === This study successfully used the modified fiber membrane to improve the filtration efficiency for blood separation in the rapid test strip.The fiber membrane had the specific pore size which can generate the physical barriers to remain the blood cells and used the chemical modification method to decrease the hemolysis and thrombus conditions in the rapid test strip. Modified fiber membrane can improve the filtration efficiency to decrease the interference of the background value in the rapid test strips. This study was discussed the filtration efficiency in FABP strip under different material of the fiber membrane(Polyether sulfone, Mixed cellulose ester and Acetate cellulose), different membrane pore sizes(0.22 µm, 0.8 µm, 1.2 µm, 2 µm and 5 µm), different chemical modification method(thermal decomposition method and the hydrogen peroxide oxidation method), different chemical modification temperature(60°C, 70°C, 80°C and 90°C), different Heparin concentration(1 IU/mL, 10 IU/mL and 100 IU/mL). When the fiber membrane is Acetate cellulose and pore size is 2 µm which is used the thermal decomposition method to modify the fiber membrane under modification temperature is 80°C and Heparin concentration is 100 IU/mL, the grayscale of the test strip background increased from 190 to 230, and filtration efficiency was increased to 21%, but the grayscale of result line and control line is still 180 and 140. Therefore, this modified fiber membrane can improve the filtration efficiency and the discrimination by decreasing the interference of the background value in the rapid test strips.