Palladium Catalyzed Coupling Reactions Employing Quinoline Secondary Phosphine Oxide Ligands

• Main Authors: Wei-Chan Chang, 張惟程
• Other Authors: 洪豐裕
• Format: Others
• Language: zh-TW
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/94830267598265193464

碩士 === 國立中興大學 === 化學系所 === 101 === Several quinoline-type secondary phosphine oxide ligands (SPOs, 2a-2e) were prepared and characterized. An unexpected palladium complex 6c was obtained from the reaction 2c with Pd(COD)Cl2 or [PdCl(allyl)]2 with high yield. The structure of 6c reveals that the palladium metal is coordinated by a sole chloride and two 2c ligands in a bis-bidentate manner. The square pyramidal structure of 6c is rare for a Pd(II) complex. Applications of these SPOs in Suzuki-Miyaura and Heck reactions exhibit fair to excellent efficiencies. 2c also acts as a competent ligand for palladium catalyzed three-component reaction including norbornene, 2-iodophenol and CO.