| Summary: | 碩士 === 美和科技大學 === 健康與生技產業研究所 === 101 === Secondary metabolites is applied in the human life of the Chinese herbal medicine. Many drugs are originally extracted from natural product with combination of pharmaceutical and chemical studies. However, the new drugs is a combination of the new natural product and small molecular drugs as well.The purpose of this studies, is extracted and investigated the compound activity of Taiwan endemic plant of seed from Gonocaryum calleryanum (Baill.) Becc.In preliminary result the ethyl acetate extracted from Gonocaryum calleryanum (Baill.) Becc. which the anti-insulin demonstrated the induced of FL83B cells in mouse liver. Therefore, the screening compound can be potentially as the substance in induction of treating cells with TNF-α diabetes mellitus.In this study, successfully isolate a series of new natural products, including four new natural products Gonocarin A (1), Epi-gonocarin A (2), Gonocarin B (5), Gonocarin C (6), and two new derivatives Gonocarin A monoacetate (3), Epi-gonocarin A monoacetate (4) and two known compounds Pinoresinol (7) and Paulownin (8) were isolated from the Taiwan endemic plant Gonocaryum calleryanum (Baill.) Becc.
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