Investigation of optimization of nanonized lipid carrier of drugs for enhanced transdermal delivery

• Main Authors: Chi-Te Huang, 黃繼德
• Other Authors: Yi-Hung Tsai
• Format: Others
• Language: zh-TW
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/05113392974659693516

博士 === 高雄醫學大學 === 藥學研究所 === 101 === Transdermal delivery system had lots of potentials as a rout for new dosage development, such as noninvasive way, non-GI absorption, which can avoid the disadvantages caused by COX-1 inhibition or serotonin. The propose of this research is to develop a novel transdermal drug delivery system with microemulsion and evaluate physical and chemical properties such as Zeta potential, particle size, and in vitro transdermal delivery. Preliminary result has been found by experimental design. The flux and lag time of the meloxicam potassium and citalopram microemulsion formulation are (31.25 mg/cm2/h; 180.23 ng/cm2/h )and (2.84 h; 1.60h), is close to the values from real transdermal experiment (27.40 ±1.02; 179.63±20.44 mg/cm2/h) 和( 3 ±1; 1.67±0.58 h). For the animal study, the formulation revealed no irritation effect and cad easily reached the minimum effective concentration. It shows that its available to use experimental design for microemulsion formulation development for transdermal delivery system.