Concise Synthesis of Fanetizole, Quinolines and Quinoxalines in PEG-400

• Main Authors: Shu-Ching Chang Chien, 張簡淑青
• Other Authors: Mei-Ing Chung
• Format: Others
• Language: zh-TW
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/24983422152353691718

碩士 === 高雄醫學大學 === 藥學研究所 === 101 === Polyethylene glycols (PEG) are well-known to be inexpensive, recoverable, non-toxic, thermally stable, and biological compatible polymers. Polyethylene glycols are most commonly employed as a support or a phase-transfer catalyst in various organic transformations. Compared with classical molecular solvents, the polyethylene glycols are environmentally benign reaction media. To date some of the more important reactions have been carried out and investigated in PEG-400. Hypervalent iodine(III) compounds have been extensively used in organic syntheses due to their low toxicity, ready availability and easy handling [Hydroxyl(tosyloxy)iodo]benzene (HTIB), phenyliodine(III) diacetate (PIDA) and phenyliodine(III) bis(trifluoroacetate) (PIFA) are the most frequently used and easily available reagents in the family of iodine compounds. In this work, catalytic reaction of hypervalent iodine(III) reagent and PEG-400 will be applied to prepare fanetizole, quinolines and quinoxalines. The method is simple, rapid and practical, the most valuable is benign to environment and generating target compounds in good yields.