| Summary: | 碩士 === 義守大學 === 生物醫學工程學系 === 101 === Diffusion tensor imaging (DTI), a novel non-invasive method of magnetic resonance imaging (MRI), has been wildly used in neurophysiology, neurons anatomy and multiple sclerosis diagnosis and research. Brain white matter tracts’ fractional anisotropy (FA) was significantly higher than gray matter, and sensitive to white matter in diffusion tensor imaging as well. Diffusion anisotropy changes with diseases and also with neural developments. Therefore, diffusion tensor imaging was used to acquire image data and to investigate changes in regional diffusion quantitative indices, mean diffusivity (MD), FA, and white matter fiber tract during rabbit brain developments. The results were evaluated and compared longitudinally. DTI is able to fully document integrity of neural fiber tracks and presents tissue’s microstructure in rabbit brain in vivo. The goal of this study was to study changes in regional diffusion quantitative indices and white matter fiber tract of animal brain development model. In order to present neural fiber tractography and diffusion characteristics in different regions of rabbit’s brain, time course MD, FA and MR tractography of normal New Zealand rabbits were statistically quantified longitudinally. The results showed that the MD values in each part of the New Zealand rabbits’ brain gradually decreased as they became older. On the contrary, the FA values in each part of the brain showed significantly increased as the New Zealand rabbit getting older. DTI tractography also showed that the brain neural fibers became denser and gradually showing integrity as the New Zealand rabbits getting older. Hence, it might be capable of investigating the developmental process of brain neural fiber longitudinally. It is hoped that the achievements of this study can be further applied in clinical diagnosis.
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