| Summary: | 碩士 === 弘光科技大學 === 生物科技研究所 === 101 === Benign prostatic hyperplasia (BPH), an imbalance between androgen/estrogen, overexpression of stromal and epithelial growth factors associated with chronic inflammation, has become an atypical direct cause of mortality of aged male diseases. Ginkgo possesses anti-inflammatory, blood flow-enhancing, and free radical scavenging effects. Considering strenuous exercise can reduce BPH risks, we hypothesize Ginkgo+exercise (Ginkgo+Ex) could be beneficial to BPH. In our study , we create a animal model to reveal the influence of Ginkgo or Exercise to BPH.Ginkgo alone in BPH induction model had no effect on T, 5α-reductase, and dihydrotestosterone (DHT), but suppressed androgen receptor (AR), aromatase, E2 and estrogen receptor (ER), and the proliferating cell nuclear antigen (PCNA) ; Ex alone significantly reduced T, aromatase, E2, ER, AR, and PCNA, but highly raised DHT. While Ginkgo+Ex androgenically downregulated T, aromatase, E2 and ER, but upregulated DHT, AR, and PCNA, implying Ginkgo+Ex tended to worsen BPH.Thus, Ginkgo or Ex alone may be more beneficial than Ginkgo+Ex for treatment of BPH.
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