Dibenzoylmethane and its analogues suppress in vitro metastasis of human HeLa cervical cancer cells

• Main Authors: Sung-en Wu, 吳宋恩
• Other Authors: Ya-fan Liao
• Format: Others
• Language: zh-TW
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/30629743350820125249

碩士 === 朝陽科技大學 === 應用化學系生化科技碩士班 === 101 === Dibenzoylmethane (DBM) is extracted from Glycyrrhiza glabra and its structure is similar to curcumin. It has been shown to exhibit antineoplastic effects, cell cycle arrest and apoptosis. Metastatic cervical cancer often is difficult to treat and a poor prognosis. Therefore, the inhibition of metastasis could prevent tumor progression. In this study, we investigated the effects of DBM and its analogues including 1-(2-Hydroxyphenyl)-3-phenyl-1,3-propanedione (HDB) and 1-(2-Hydroxyphenyl-5-methylphenyl)-3-phenyl-1,3-propanedione (HMDB) on the metastasis of human HeLa cervical cancer cells. DBM and its analogues caused the dose-dependent decrease of cell viability in HeLa cells. Furthermore, they reduced the migration and invasion of HeLa cells. Matrix metalloproteinase-2 (MMP-2) plays the important role in cancer cell invasion. MMP-2 expression and activity were inhibited in DBM-, HDB- and HMDB-treated HeLa cells. Dysfunction or loss of E-cadherin/