Iodine and Microwave Catalyzed Synthesis of Bioactive Compounds

• Main Authors: Li, Ni-Ching, 李妮靜
• Other Authors: Cherng, Yie-Jia
• Format: Others
• Language: zh-TW
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/21340793366254173557

碩士 === 中臺科技大學 === 醫學檢驗生物技術系碩士班 === 101 === Abstract Using the iodine and the microwave heating, successfully synthesize the multi-ring heterocyclic organic compounds. They are an important class of molecules with physiological significance and pharmaceutical utility. For example, thiazepines, oxazepines, benzothiazoles and benzimidazoles. Especially for an additional fused aromatic ring in dibenzo[b, f][1,4]thiazepine and dibenzo[b,f][1,4] oxazepine, has also received intensive attention. Various synthetic routes for the preparation of 7-membered rings with two heteroatoms have reported in the literature. Thiazepines and pyrrole derivatives belong to an important class of compounds possessing a wide variety of medicinal properties, like bile pigment, Vitamin B12, chlorophyll and relative natural products. The serotonin derivatives fulfill multiple physiological roles in both the central and peripheral nervous system by acting on a diversity of receptor subtypes widely distributed in the organism. Some antagonists of this 5-HT receptor subtype (e.g., ondansetron or granisetron) are of high therapeutic interest in the prevention and treatment of vomiting associated with anticancer chemotherapy. Another therapeutic use suggested for this class of compounds is regulation of gastrointestinal motility. In recognition of microwave’s important effect, many of oil heating methods still need long reaction time to improve the yield. We demonstrate herein a novel and efficient synthesis of bioactive compounds by microwave assisted.