| Summary: | 碩士 === 中山醫學大學 === 醫學研究所 === 101 === Objectives: Colorectal cancer (CRC) is the fourth highest cause of cancer deaths in worldwide. On 2008, 608,700 people deaths in colorectal cancer. MicroRNAs regulate gene expression at the post-transcriptional level and play important roles in tumor development, progression, and metastasis. The aim of this study was to investigate the correlation between microRNA 92a (miR-92a) and E-cadherin expression in colorectal cancer.
Materials and methods: A total of 158 colorectal cancer patients were enrolled . MiR-92a and E-cadherin were analyzed by real-time PCR.
Results: The expression levels of miR-92a in tumor tissues were significantly positive correlated with lymph node metastasis of CRC patients (p=0.012).After adjusting for age, gender and differentiation status, this correlation remained significantly (p=0.01). In addition, expression levels of E-cadherin was not correlated with lymph node metastasis(p=0.728).The correlation of miR-92a and E-cadherin gene was not significant in this study (p=0.056).
Conclusion: We found that high expression of miR-92a was positive correlated with lymph node metastasis inCRC. But expression levels of E-cadherin was not correlated with lymph node metastasis. Down-regulation of E-cadherin gene in CRC was not associated with miR-92a up-regulation .Thus, we suggested that miR-92a involved in lymph node metastasis of CRC patients may not through E-cadherin down-regulation .
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