| Summary: | 碩士 === 中山醫學大學 === 醫療產業科技管理學系碩士班 === 101 === The study subjects in this research were women and their first offsprings. Women who suffered pregestational diabetes or suspected diabetes during 2004 to 2009 and their first offsprings were included to explore the risk factors of birth defects, and the association between mothers’ health and babies’ birth defects.
The Birth Certificate Application, National Health Insurance Research Database, and the Birth Registration databasewere linked into the study dataset.The samples of this research are 621,008 pregnant women. Descriptive statistics and logistic regression analysis were used to analyze the dataset.
The major findings of this study are as follows:women suffering from pregestational diabetes or suspected diabetes aresignificantlyassociated with the birth defectsof their firstoffsprings. In addition, the first offsprings of women who suffer frompregestational diabeteshad higher risk of birth defects than the mothers who did not have diabetes mellitus. The higher risk of birth defects include: the nervous system defects, eyes defects, heart defects, respiratory system defects, orofacial cleft,digestive defects, urinary tract defects, limb defects, andother defects.
In the further analysis of therelationship between neonates gender, maternal age, gestational weeks, birth weight, Apgar scoreandbirth defects by univariate logistic regression analysis found that,non-diabetes and pregestational diabetes and suspected diabetes groups indicate that, with the increasing number of gestationweeks, birth weight, the Apgar scoreof the first minute and the fifth minute of newborn,the risk of birth defectsprones to decrease;with the increase of maternal age,the risk of birth defects also prones to increase; another finding in this research is that the risk of birth defects in boysare significantly higher than girls.
In conclusion, women with pregestational diabetes, or suspected diabetics is the factor of increasingthe risk of birth defects in the offspring, while maternal age, gestational age, birth weight, and the Apgar scoreof the first minute and the fifth minute of newborns has a significant relationship with birth defects.
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