| Summary: | 碩士 === 中山醫學大學 === 營養學研究所 === 101 === A high oxidative stress and inflammation may contribute to the pathogenesis of metabolic syndrome (MS). Graptopetalum paraguayense E. Walther is a traditional Chinese herbal medicine and is widely consumed in Taiwan. The purpose of this study was to investigate the effect of aqueous extract of (Graptopetalum paraguayense E. Walther water extracts, GWE) (4 g/day) on the levels of lipid peroxidation, antioxidant enzymes activities, antioxidant vitamins, and inflammatory markers in patients with MS. Subjects with MS were recruited from the Department of Family and Community Medicine of Chung Shan Medical University Hospital in Taiwan (n = 54) and randomly assigned to the placebo (n = 28) and GWE (n = 26) groups. The levels of fasting glucose (FG), blood pressure [systolic blood pressure (SBP) and diastolic blood pressure (DBP)], lipid profiles [total cholesterol (TC), triglyceride (TG), low density lipoprotein-cholesterol (LDL-C) and high density lipoprotein-cholesterol (HDL-C)], malondialdehyde (MDA), antioxidant enzymes activities [superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT)], antioxidant vitamins (vitamin A and E), and inflammatory markers [high sensitivity-C reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and adiponectin (AD)] were measured. Forty-two subjects were completed 12 weeks intervention (placebo groups, n = 19; GWE groups, n = 23). Subjects in the GWE group had significantly higher levels of HDL-C (p = 0.01), antioxidant enzymes activities (SOD and CAT, p < 0.01), and lower FG (p = 0.04), SBP (p = 0.01), LDL-C (p = 0.04), inflammatory markers (hs-CRP, IL-6 and TNF-α, p < 0.05) than the placebo group at week 12. The levels of HDL-C (p = 0.02), antioxidant enzymes activities (SOD and CAT, p < 0.05) were significantly increased and the levels of SBP (p < 0.01), inflammatory markers (hs-CRP and TNF-α, p < 0.05) were significantly decreased in GWE group after 12 weeks administration. In conclusion, administration of GWE 4 g per day to MS subjects may assist in modulating the levels of blood pressure and blood lipid, increase antioxidant enzymes activities, and reduce the inflammation.
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