Increase in antioxidative activity and regulation in blood pressure by mycelia of Antrodia cinnamomea

• Main Authors: Jing-Ting Chen, 陳靜婷
• Other Authors: 沈祐成
• Format: Others
• Language: zh-TW
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/09665968221448901837

碩士 === 中山醫學大學 === 健康餐飲暨產業管理學系碩士班 === 101 === Antrodia camphorate (AC) also called Antrodia camphorata mushrooms, or Antrodia bacteria, only grows in the aging stout camphor tree of Taiwan. Many studies showed that adenosin and γ-amino butyric acid of AC may have the effect to regulate blood pressure. This study was focused on regulation of blood pressure. Firstly, we used HPLC analysis to find Antrodia camphorata of mycelia had active ingredients, in contain adenosin and γ-amino butyric acid, could regulate blood pressure. We also found water crude extracts of Antrodia camphorata of mycelia can inhibit of ACE activity 27.09% and reduce renin activity 36.91%. Furthermore, this study supplement Antrodia camphorata of mycelia to high blood pressure subjects. This was a randomized and placebo-controlled study, enrolled total 48 subjects with high blood pressure and finally completion study had 41 subjects. The subjects had no history of taking anti-hypertensive medications adults (20 to 65 years old), and the systolic blood pressure between 130~160 mmHg, the diastolic blood pressure between 85~99 mmHg in the trial. Each group took 3 granule of Antrodia camphorate mycelia or placebo per day during 8 weeks of administration period. Every two weeks to detect changes in blood pressure and collecd blood sampling, to determine blood sugar, blood lipids, blood urea nitrogen, GOT, GPT, and other biochemical markers. The results of this study found that continuous use Antrodia camphorate mycelia for 8 weeks, significant decrease 10.01mmHg and 5mmHg of systolic and diastolic blood pressure respectively. Continuous taking Antrodia camphorata of mycelia after 4 weeks significantly reduced plasma renin activity. By the way, water extract mycelia could inhibit angiotensin converting enzyme of 27.09% and reduced renin activity of 36.91%. Therefore, taking Antrodia camphorata of mycelia could be down-regulate blood pressure.