| Summary: | 碩士 === 中國醫藥大學 === 物理治療學系復健科學碩士班 === 101 === Benign prostatic hyperplasia (BPH) is one of the most common diseases among aging men. Many risk factors of the metabolic syndrome (MS) such as insulin resistance, hypertension and obesity are linked to BPH. The growth of prostatic cells is regulated by sex hormones, including estrogen, testosterone (T), dihydrotestosterone(DHT) and5α-reductase. Exercise has shown to be beneficial to MS. The development of BPH is inversely related to exercise. In this present study, the combined BPH-diabetes (DM) rat model was used to investigate the effect of exercise on BPH. Results showed that exercise alleviated the ratio of prostate to body weight in DM group and also regulates it’s testosterone level, exercise also altered DHT level in both DM and BPH+DM groups. Besides, exercise only showed its effect on reversing interleukin-6 (IL-6) in BPH+DM group to normal. Exercise was likely less benefit on ameliorating inflammation. As the conclusion, exercise was beneficial by hormone regulation on abnormal growth of prostates in DM group.
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