The effect of Ligusticum chuanxiong on learning disabilities and the function of liver and kidney in streptozotocin-induced hyperglycemic rats

• Main Authors: Yu-Chieh Chou, 周于傑
• Other Authors: 吳啟瑞
• Format: Others
• Language: zh-TW
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/89275279908088710598

碩士 === 中國醫藥大學 === 中國藥學暨中藥資源學系碩士班 === 101 === This study investigated the effect of Chuanxiong for streptozotocin (STZ)-induced hyperglycemic rats in learning and memory, liver and kidney function, and determination in the brain and other organs of the antioxidant enzymes, then we could find Chuanxiong for hyperglycemia rat have the ability to improve memory and learning as well as other functions. In this study, rats were divided into seven groups (1) control (2) STZ-induced hyperglycemia (3) low-dose of Chuanxiong crude extract (4) high-dose of Chuanxiong crude extract (5) low-dose TMP (6) high-dose TMP (7) ferulic acid. The experimental results showed that the crude extract of Chuanxiong for STZ-induced hyperglycemia rats have the effect of reduce blood glucose, and liver function in STZ-induced rat would cause damage in the blood γ-GT, GOT and GPT levels significantly increases. In renal function, STZ-induced hyperglycemia rats is similar to the control group. STZ-induced hyperglycemic rats in learning, memory and liver function may have the injury situation, and Chuanxiong crude extract and ferulic acid may reply by AChE activity in the plus-maze and water maze.We could seen for that the hyperglycemia rats improved learning and memory. In liver function, Chuanxiong and TMP decreased MDA to improve or repair the liver function. The content of STZ-induced hyperglycemia in the hippocampus AChE was significantly lower, in total GSH, total SOD and Mn-SOD would reduced the content , while in the hippocampus, liver and kidney MDA level had elevated. It was found the STZ-induced hyperglycemia group in plus maze, water maze and probe have learning and memory impairment problems, and then give Chuanxiong crude extract, high doses of TMP and ferulic acid for STZ-induced hyperglycemia rat.Their learning and memory impairment has improved.