Control and monitoring of brain drug delivery using dual-confocal ultrasound transducer

• Main Authors: Chih Hung Tsai, 蔡至洪
• Other Authors: H.L. Liu
• Format: Others
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/99673137088567266458

碩士 === 長庚大學 === 電機工程學系 === 101 === Burst-mode focused ultrasound (FUS) exposure combined with the presence of micro-bubbles has been proved to induce local and reversible blood-brain barrier (BBB) opening effect, and can be served as an effective approach to deliver therapeutic molecules into the brain.. However, the current FUS-BBB opening effect is post-operatively observed and validated with the use of contrast-enhanced magnetic resonance imaging, and cannot be monitored intra-operatively. In addition, brain and skull heterogeneity, experimental conditions such as micro-bubbles dose injection variations all leads to the uncertainty of the BBB-opening and makes the procedure uncontrollable.. This thesis aims to explore the use of confocal contentric-ring type focused ultrasound transducer to perform the FUS-BBB opening and simultaneously record the echo signal at the focal positions to explore the possibility of real-time BBB opening observation. In addition, this thesis also proposed a possible scheme to use this recorded echo signals to serve as an index to implement a feedback control scheme under a self-developed control integration interfaces and environment.