A study on the preparation of biodegradable PHBV microparticles and its drug release

• Main Authors: Chih-Yu Tsai, 蔡志煜
• Other Authors: I-MingChu
• Format: Others
• Language: zh-TW
• Online Access: http://ndltd.ncl.edu.tw/handle/48836090501811019992

碩士 === 元智大學 === 生物科技與工程研究所 === 100 === Infection is one of the most serious problems in implantation surgery. The utilization of drug delivery systems in surgical procedures offers an addition therapeutic approach to the treatment of infection and the possibility of minimization of the systemic use of drug, and delivering an effective antimicrobial at a sufficiently high concentration to the area of infection in combination. Many degradable polymers have been used as drug delivery systems in implantation surgery. Biodegradable and biocompatible materials, Poly(3-hydroxybutyrate) (PHB) and its copolymers poly(hydroxybutyrate-cohydroxyvalerate) (PHBV) are the most widely used poly(hydroxyalcanoates) (PHAs). Gentamicin and vancomycin are the most extensively used to treat osteomyelitis. In this study, PHBV microparticles without hight drug encapsulation efficiency (E.E.) were prepared by an water-in-oil-in-water (w/o/w) emulsion/solvent evaporation technique. Precipitation method preparation of microparticles increase drug encapsulation efficiency to 26.96%. PHBV/chitosan and PHBV/PEG microparticles drug E.E. to 34.31 and 26.2% separately. Vancomycin elution was enhanced by 178% with the addition of gentamicin.