Nickel-Catalyzed Intermolecular Insertion of Aryl Iodides to Nitriles

• Main Authors: Yen-Chung Chen, 陳彥中
• Other Authors: Jen-Chieh Hsieh
• Format: Others
• Language: zh-TW
• Published: 2012
• Online Access: http://ndltd.ncl.edu.tw/handle/92039011695922950605

碩士 === 淡江大學 === 化學學系碩士班 === 100 === We have developed a novel methodology for the intermolecular insertion of aryl iodides to nitriles catalyzed by a nickel complex.Up to now, there has been no example of using firstrow transition metal complexes as catalyst for the addition of aryl iododes to nitriles.This is the first report that nitriles can undergo intermolecular insertion with aryl iodides to furnish various arylketone derivatives in moderate to excellent yields with tolerance of a very wide variety of functional groups. Further studies to explore the possibility for the synthesis of various chromones as well as to extend the application of this catalytic system are currently underway.