| Summary: | 碩士 === 國立臺北科技大學 === 材料科學與工程研究所 === 100 === Dicalcium phosphate dehydrate ( DCPD ) is the major component of hard tissues like bone and teeth, which is non-toxic, biocompatibility and biodegradable. In this study, the Fe-DCPD particles was formed by co-precipitation method. The iron ions can substitute calcium ions of DCPD and form a magnetic DCPD；by doing this it can release heat in alternating magnetic field because it has magnetism. As temperature rise up to 43~46℃, the heat treatment will cause cancer cells dead.
However, in order to extend the blood circulation time and convenient graft, the surface modification is necessary. Surface modification use the natural polymer chitosan. Last in modify folic acid (FA) on the magnetic particle surface, improve the targeting rate. It is believed that magnetic Fe-DCPD/Chitosan-FA is one of the most potential materials in lung cancer hyperthermia by using in halation in the future.
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