Thermosensitive copolymer with chitosan particals

• Main Authors: Ying-Ru Chen, 陳盈如
• Other Authors: Kuo-Chung Cheng
• Format: Others
• Language: zh-TW
• Published: 2012
• Online Access: http://ndltd.ncl.edu.tw/handle/ctfsg7

碩士 === 國立臺北科技大學 === 生物科技研究所 === 100 === Poly(NIPAAm-PEGMEA) copolymers were prepared via free radical polymerization of various mole ratios of monomers initialized by H2O2-vitamin C redox initiators. The synthesized copolymers were further mixed with chitosan particles in phosphate buffered saline (PBS). The temperature dependences of flow property and cloud point of the solution with chitosan particles were investigated by the tube-invert, DSC, and light transmission tests. It was found that the poly(NIPAAm) could flow at 25oC, and formed a gel at higher temperature. The cloud point of the Poly(NIPAAm-PEGMEA) could increased to about 36.4oC with increasing of PEGMEA unit, but there had almost no change with addition of chitosan particles. The thickness of the poly(NIPAAm), and poly(NIPAAm-PEGMEA) hydrogels could increased to 40% and 80%, respectively, higher than that before swelling in PBS at 37oC. The ratio became only 50% for the poly(NIPAAm-PEGMEA)/chitosan particle system. The MTT assay indicated the biocompatibility could be improved by adding the chitosan particles into the copolymer hydrogel.