Study of collagen/hyaluronic acid/tricalcium phosphate composites

• Main Authors: ZHONG-RUI LIU, 劉中瑞
• Other Authors: 鍾仁傑
• Format: Others
• Language: zh-TW
• Published: 2012
• Online Access: http://ndltd.ncl.edu.tw/handle/8pdt6e

碩士 === 國立臺北科技大學 === 化學工程研究所 === 100 === In this study, composite restoration materials (CHTP) made of type I collagen, hyaluronic acid (HA) and tricalcium phosphate (β-TCP) were prepared and crosslinked with the natural crosslinking agent, oligomeric proanthocyanidins (OPCs). The crosslinking property was evaluated. The mechanical strength, swelling ratio and in vitro degradation rate of the optimally crosslinked CHTP composite were investigated. In vitro tests were carried out to evaluate the biocompatibility using MG-63 cell line. Results indicated that the crosslinked composite using 5% OPCs solution (CHTP-5%) had high swelling ratio (420%) and mechanical strength (40 kPa), and remained more than 60% weight after 30 days in vitro degradation test. The results of in vitro tests showed that CHTP-5% would promote the proliferation of MG-63 cell. The results of material analyses and in-vitro tests showed that CHTP-5% composite is of great potential to serve as a useful bone restoration material.